Hydrochloric Acid → HCID 66547916, compound

Participants

Reaction Steps

To isopropyl-[3-(2-methanesulfonyl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-carbamic acid tert-butyl ester (117 mg, 0.27 mmol) (from Example 11 supra) was added aniline (38 μL, 0.42 mmol) in nBuOH (3 mL) followed by conc.HCl (38 μL, 0.46 mmol) and the reaction was shaken at 95° C. overnight. After this time the reaction was concentrated to dryness, dissolved in DMSO (1.8 mL) and then purified by preparative HPLC to give isopropyl-[3-(2-phenylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine. (Yield 27.3 mg, 29%). LC-MS: [M+H]+ 346.3.

Provenance & Evidence