Morpholine → (2-Methanesulfonyl-ethyl)-[3-(2-morpholin-4-yl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	2-(Methylthio)-4-(tributylstannyl)pyrimidine	HCID 2763261	—
Reactant	(3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester	HCID 68226902	—
Product	(2-Methanesulfonyl-ethyl)-[3-(2-morpholin-4-yl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine	HCID 66548083	—

Reaction Steps

(2-Methanesulfonyl-ethyl)-[3-(2-morpholin-4-yl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and morpholine. LC-MS: [M+H]+ 404.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673905B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-5d4fdea8d9564a2c8ff201151a6c2d67
Source note	uspto-grants-2014_03