HCID 68227053, compound → HCID 66548085, compound

HRID 1186471Notes

Reaction equation

HRID 1186471 reaction equation
C(OC(=O)[N:7]([CH:25]([CH3:27])[CH3:26])[C:8]1[C:9]2[N:10]([C:14]([C:17]3[CH:22]=[CH:21][N:20]=[C:19](SC)[N:18]=3)=[CH:15][N:16]=2)[CH:11]=[CH:12][N:13]=1)(C)(C)C.[NH2:29][C@H:30]1[CH2:35][CH2:34][C@H:33]([OH:36])[CH2:32][CH2:31]1>>[CH:25]([NH:7][C:8]1[C:9]2[N:10]([C:14]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:29][CH:30]4[CH2:35][CH2:34][CH:33]([OH:36])[CH2:32][CH2:31]4)[N:18]=3)=[CH:15][N:16]=2)[CH:11]=[CH:12][N:13]=1)([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 68227053HCID 68227053, compoundHCID 178511715HCID 178511715, compound

Product 1

HCID 66548085HCID 66548085, compound

Procedure

4-[4-(8-Isopropylamino-imidazo[1,2-a]pyrazin-3-yl)-pyrimidin-2-ylamino]-cyclohexanol was prepared by a process analogous to that described in Example 12 starting from isopropyl-[3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-carbamic acid tert-butyl ester (from Example 11 supra), and trans-4-amino-cyclohexanol. LC-MS: [M+H]+ 368.3.

Sources & evidence

ORD record
ord-47657dd674af43758d3a0d688f6bfa45
Source dataset
uspto-grants-2014_03
Patent number
US08673905B2

Reaction notes

Loading…