4-Aminotetrahydropyran → 2-{3-[2-(Tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-ylamino}-ethanol

Participants

Role	Name	HCID	Charge
Reactant	4-Aminotetrahydropyran	HCID 419223	—
Reactant	2-(Methylthio)-4-(tributylstannyl)pyrimidine	HCID 2763261	—
Reactant	2-[(3-Bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethan-1-ol	HCID 21070904	—
Product	2-{3-[2-(Tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-ylamino}-ethanol	HCID 66548263	—

Reaction Steps

2-{3-[2-(Tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-ylamino}-ethanol was prepared by a process analogous to that described in Example 12 starting from 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol (from Example 2 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 356.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673905B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-7c293091818d4a45b19abed0a403d574
Source note	uspto-grants-2014_03