HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-[3-(2-Methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | HCID 2763261 | — |
| Reactant | 2-[(3-Bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethan-1-ol | HCID 21070904 | — |
| Product | 2-[3-(2-Methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-ethanol | HCID 66548439 | — |
Reaction Steps
2-[3-(2-Methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-ethanol was prepared by a process analogous to that described in Example 12 starting from 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol (from Example 2 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and methylamine. LC-MS: [M+H]+ 286.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673905B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-9a53e6341d92478dbbcb909c61d09903 |
| Source note | uspto-grants-2014_03 |