m-Chloroperbenzoic acid → HCID 68226572, compound

Participants

Reaction Conditions

Reaction Steps

{4-[3-(2-Methylsulfanyl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester (from Example 47 supra) (150 mg, 0.323 mmol) was dissolved in dichloromethane (20 mL), then m-CPBA (134 mg, 0.659 mmol) was added slowly. The reaction mixture was stirred at 0° C. for 2 hours. The solvent was removed under reduced pressure and the solid was purified by chromatography (silica gel, 10 g, 200-300 mesh, eluting with dichloromethane:methanol, 20:1) to afford {4-[3-(2-methanesulfinyl-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester. (Yield 110 mg, 70.8%). LC-MS: [M+H]+ 472.

Provenance & Evidence