Cyclohexene → N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-amino-2-[tetrahydro-2H-pyran-4-yl(trifluoroacetyl)amino]benzamide

참여 물질

역할	이름	HCID	투입량
반응물	Cyclohexene	HCID 8079	—
반응물	N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-nitro-2-[tetrahydro-2H-pyran-4-yl(trifluoroacetyl)amino]benzamide	HCID 86647627	—
촉매	Palladium	HCID 23938	—
용매	1,4-Dioxane	HCID 31275	—
생성물	N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-amino-2-[tetrahydro-2H-pyran-4-yl(trifluoroacetyl)amino]benzamide	HCID 86647628	82%

반응 조건

온도	100 °C

반응 단계

A mixture of N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-nitro-2-[tetrahydro-2H-pyran-4-yl(trifluoroacetyl)amino]benzamide (3.86 g, 6.4 mmol), cyclohexene (10 mL), dioxane (70 mL) and 10% Pd/C (0.42 g) was stirred at 100° C. for 4 hours. The reaction mixture was filtered over a celite pad washing thoroughly with THF and MeOH. After evaporation of the organic phase, purification of the crude by chromatography over silica gel (DCM/EtOH 9/1) gave 2.75 g of title compound (82% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08673893B2
출처 데이터셋	uspto-grants-2014_03
ORD ID	ord-7a723b0d88d641e5b580aa43d501302d
출처 메모	uspto-grants-2014_03