Benzenesulfonamide, N-(4-methylphenyl)-4-nitro- → 4-amino-N-p-tolylbenzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Benzenesulfonamide, N-(4-methylphenyl)-4-nitro-	HCID 293081	—
Reactant	4-amino-N-(2-methylphenyl)benzene-1-sulfonamide	HCID 593569	—
Product	4-amino-N-p-tolylbenzenesulfonamide	HCID 572102	99%

Reaction Steps

(RK1-1-30)I This compound was prepared according to the procedure for compound 12a except using 11d to obtain the required product as an off-white solid (225 mg, 99%). Mp=174-176° C. (lit 190-190.5° C., Bioorganic and Medicinal Chemistry 15(2), 1014-1021; 2007); 1H NMR (400 MHz, CDCl3) δ 7.43 (d, J=8.8 Hz, 2H), 6.96 (d, J=8.4 Hz, 2H), 6.86 (d, J=8.4 Hz, 2H), 6.52 (d, J=8.8 Hz, 2H), 6.14 (br s, 1H), 4.00 (br s, 2H), 2.20 (s, 3H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673910B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-5f1b80220ada47d2a5f9414f23713afa
Source note	uspto-grants-2014_03