Ethyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetate → Methyl 3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanoate

HRID 1186659Notes

Reaction equation

HRID 1186659 reaction equation
OC1C2C(=CC=CC=2)C(NS(C2SC=CC=2)(=O)=O)=CC=1SCC(OCC)=O.[O:28]=[C:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:32](=[N:39][S:40]([C:43]2[S:44][CH:45]=[CH:46][CH:47]=2)(=[O:42])=[O:41])[CH:31]=[C:30]1[S:48][CH2:49][CH2:50][C:51]([O:53][CH3:54])=[O:52]>>[OH:28][C:29]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:32]([NH:39][S:40]([C:43]2[S:44][CH:45]=[CH:46][CH:47]=2)(=[O:42])=[O:41])=[CH:31][C:30]=1[S:48][CH2:49][CH2:50][C:51]([O:53][CH3:54])=[O:52]

Participants

3

Reactant 2

HCID 44608823Ethyl 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetateHCID 67332223Methyl 3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanoate

Product 1

HCID 44608824Methyl 3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanoate

Procedure

5.2.22 Methyl 3-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)propanoate (9b) was prepared according to the procedure for 9a except using 8b affording 28 mg (93%) title compound as a pale yellow solid without column purification, m.p.: 117-119° C.

Sources & evidence

ORD record
ord-9a270e32fb594b7c8b7a0bdbdc03a2de
Source dataset
uspto-grants-2014_03
Patent number
US08673910B2

Reaction notes

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