HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamide → N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamide | HCID 44608656 | — |
| Reactant | 4,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide | HCID 67330668 | — |
| Reactant | 3-mercapto-N-cyclopropylpropanamide | HCID 86656567 | — |
| Product | N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide | HCID 67330263 | — |
Reaction Steps
5.2.43 N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide (13h) was prepared according to the procedure for 13d except using 4,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophenesulfonamide (12c) and 3-mercapto-N-cyclopropylpropanamide which afforded the title compound 20 mg (37%) as a yellow solid, m.p.: ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673910B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e70cfc4352a9457d937cb9b8a5009772 |
| Source note | uspto-grants-2014_03 |