HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-{[1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yl]sulfanyl}acetic acid → 2-(4-(4-Chlorophenylsulfonamido)-1-hydroxynaphthalen-2-ylthio)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-{[1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yl]sulfanyl}acetic acid | HCID 1582605 | — |
| Reactant | 4-chloro-N-(3-chloro-4-oxo-1(4H)-naphthalenylidene)benzenesulfonamide | HCID 9601233 | — |
| Reactant | HCID 178473673 | HCID 178473673 | — |
| Product | 2-(4-(4-Chlorophenylsulfonamido)-1-hydroxynaphthalen-2-ylthio)propanoic acid | HCID 44609309 | — |
Reaction Steps
5.2.63 2-(4-(4-chlorophenylsulfonamido)-1-hydroxynaphthalen-2-ylthio)propanoic acid (14u) was prepared according to the procedure of procedure B for 10a except using thiolactic acid and (E)-4-chloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)-benzenesulfonamide (12e), which afforded the title compound 41.3 mg (49%) as a white solid, m.p.: 177-179° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673910B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-eb07eea74f934dbba37e37c2ac446d01 |
| Source note | uspto-grants-2014_03 |