HCID 58121056, compound → HCID 10377040, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-hydroxy-2-(phenylethynyl)benzamide 37 (40 mg, 0.169 mmol) in EtOAc (1533 μL) and MeOH (153 pit) was degassed under vacuum and put under N2 atmosphere (3 cycles). Then a suspension of Pd/C (17.94 g, 0.017 mmol) in EtOAc (1 mL) was added and the resulting suspension was degassed and put under H2 atmosphere (3 cycles) and the resulting black suspension was stirred at 21° C. for 2 h. The reaction mixture was filtered through Celite®. The filtrate was concentrated in vacuo then crystallized from a mixture of Et2O and hexane to afford title compound 38 (25 mgs, 62% yield) as a white solid. 1H NMR: (DMSO-d6) δ (ppm): 10.90 (s, 1H), 9.10 (s, 1H), 7.37-7.22 (m, 8H), 7.18 (t, J=7.2 Hz, 1H), 2.93 (dt, J=9.8, 6.3 Hz, 2H), 2.84 (dt, J=9.7, 5.7 Hz, 2H). LRMS (ESI): (calc.) 241.29 (found) 242.22 (MH)+

Provenance & Evidence