Potassium Carbonate → HCID 67994323, compound

Participants

Reaction Conditions

Reaction Steps

An anhydrous toluene (40 mL) suspension of 1-nitronaphthalen-2-yl triflate (3.00 g, 8.64 mmol), 3-aminobenzonitrile (1.02 g, 8.64 mmol), potassium carbonate (1.19 g, 8.64 mmol), triphenylphosphine (227 mg, 0.864 mmol), and tetrakis(triphenylphosphine)palladium (500 mg, 0.432 mmol) was stirred at 110° C. for 18 hours. After cooling on standing, the reaction mixture was filtered, and the filtrate was diluted with ethyl acetate. The obtained organic solution was washed with a saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=99/1) to obtain the titled compound as a yellow powder (1.60 g, yield 64%).

Provenance & Evidence