Trifluoroacetic acid → HCID 56640367, compound

Participants

Reaction Steps

To a dichloromethane (15 mL) solution of 5-(3-tert-butoxycarbonylaminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (180 mg, 0.440 mmol) was added dropwise a dichloromethane (3 mL) solution of trifluoroacetic acid (2 mL) under cooling in an ice-bath. The mixture was stirred for one hour under cooling in ice-bath. The solvent was removed by evaporation under reduced pressure. The obtained solid was washed with ethyl acetate and water, and dried to obtain 4-(3-aminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (93 mg). The obtained compound was dissolved in dichloromethane (5 mL) and methanol (2 mL). To the solution, a 2M hydrogen chloride/methanol solution (0.15 mL) was added. The solvent was removed by evaporation under reduced pressure. To the obtained residue was added ethyl acetate, and the mixture was stirred at room temperature for 18 hours, filtered, and dried to obtain the titled compound as a white crystal (80 mg, yield 77%).

Provenance & Evidence