Ethylenediamine → HCID 56640438, compound

Participants

Reaction Steps

A mixture of 4-[1-[2-(trimethylsilyl)ethoxymethyl]-1H-indol-4-yl]-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (180 mg, 0.400 mmol), a 1M tetrabutylammonium fluoride/tetrahydrofuran solution (4 mL, 4.00 mmol), and ethylenediamine (260 μL, 4.00 mmol) was refluxed for 18 hours. The solvent was removed by evaporation under reduced pressure. To the obtained residue was added a dilute hydrochloric acid aqueous solution. The mixture was stirred at room temperature for 18 hours. The precipitate was collected by filtration, washed with water, and dried to obtain the titled compound (85 mg, yield 66%).

Provenance & Evidence