2-Nitrobenzenesulfonyl chloride → HCID 86690003, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(3-aminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (228 mg, 0.74 mmol), 2-nitrobenzenesulfonyl chloride (247 mg, 1.11 mmol), and dry pyridine (5 mL) was refluxed at 80° C. for 4 hours. After cooling on standing, the solvent was removed by evaporation under reduced pressure. The obtained residue was extracted with chloroform, washed with water and a dilute hydrochloric acid aqueous solution, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform/methanol=100/1) to obtain the titled compound as a brown crystal (365 mg, yield 100%).

Provenance & Evidence