Methyl iodide → HCID 86690004, compound

Participants

Reaction Steps

A mixture of N-[3-(2,3-dioxo-2,3,7,8,9,10-hexahydrobenzo[f]quinoxalin-4(1H)-yl)phenyl]-2-nitrobenzenesulfonamide (100 mg, 0.203 mmol), methyl iodide (35 mg, 0.244 mmol), potassium carbonate (30.9 mg, 0.223 mmol), and dry DMF (2 mL) was stirred at room temperature for 18 hours. To the reaction solution were added ice-cold water and a saturated aqueous sodium hydrogen carbonate solution. The precipitated crystal was collected by filtration, washed with water, and dried. The obtained crude compound was subjected to silica gel column chromatography (chloroform) to obtain N-methyl-N-[3-(1-methyl-2,3-dioxo-2,3,7,8,9,10-hexahydrobenzo[f]quinoxalin-4(1H)-yl)phenyl]-2-nitrobenzenesulfonamide (70 mg, yield 66%) from the formerly eluted fraction.

Provenance & Evidence