Benzenesulfonyl chloride → HCID 86690025, compound

HRID 1186750Notes

Reaction equation

HRID 1186750 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[CH:16]=[CH:15][C:14]4[CH2:18][CH2:19][CH2:20][CH2:21][C:13]=4[C:12]=3[NH:11][C:10](=[O:22])[C:9]2=[O:23])[CH:5]=[CH:6][CH:7]=1.[C:24]1([S:30](Cl)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[O:22]=[C:10]1[NH:11][C:12]2[C:13]3[CH2:21][CH2:20][CH2:19][CH2:18][C:14]=3[CH:15]=[CH:16][C:17]=2[N:8]([C:4]2[CH:3]=[C:2]([NH:1][S:30]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:32])=[O:31])[CH:7]=[CH:6][CH:5]=2)[C:9]1=[O:23]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 56640367HCID 56640367, compound

Product 1

HCID 86690025HCID 86690025, compoundYield 54%

Procedure

4-(3-Aminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (50 mg, 0.145 mmol) and benzenesulfonyl chloride (38 mg, 0.218 mmol) were used in a process similar to Example 9 to give the titled compound (a white crystal, 35 mg, yield 54%).

Sources & evidence

ORD record
ord-330813b122c044b1b55b4bcee5075618
Source dataset
uspto-grants-2014_03
Patent number
US08673915B2

Reaction notes

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