m-Bromobenzenesulphonyl chloride → HCID 86690026, compound

HRID 1186751Notes

Reaction equation

HRID 1186751 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[CH:16]=[CH:15][C:14]4[CH2:18][CH2:19][CH2:20][CH2:21][C:13]=4[C:12]=3[NH:11][C:10](=[O:22])[C:9]2=[O:23])[CH:5]=[CH:6][CH:7]=1.[Br:24][C:25]1[CH:26]=[C:27]([S:31](Cl)(=[O:33])=[O:32])[CH:28]=[CH:29][CH:30]=1>>[Br:24][C:25]1[CH:26]=[C:27]([S:31]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([N:8]3[C:17]4[CH:16]=[CH:15][C:14]5[CH2:18][CH2:19][CH2:20][CH2:21][C:13]=5[C:12]=4[NH:11][C:10](=[O:22])[C:9]3=[O:23])[CH:3]=2)(=[O:33])=[O:32])[CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 56640367HCID 56640367, compound

Product 1

HCID 86690026HCID 86690026, compoundYield 29%

Procedure

4-(3-Aminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (30 mg, 0.097 mmol) and 3-bromobenzenesulfonyl chloride (21 μL, 0.146 mmol) were used in a process similar to Example 9 to give the titled compound (a white crystal, 15 mg, yield 29%).

Sources & evidence

ORD record
ord-b9d12522de7d493a993d46c9b27a6c1d
Source dataset
uspto-grants-2014_03
Patent number
US08673915B2

Reaction notes

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