1-Naphthalenesulfonyl chloride → HCID 86690027, compound

HRID 1186752Notes

Reaction equation

HRID 1186752 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[CH:16]=[CH:15][C:14]4[CH2:18][CH2:19][CH2:20][CH2:21][C:13]=4[C:12]=3[NH:11][C:10](=[O:22])[C:9]2=[O:23])[CH:5]=[CH:6][CH:7]=1.[C:24]1([S:34](Cl)(=[O:36])=[O:35])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[CH:26][CH:25]=1>>[O:22]=[C:10]1[NH:11][C:12]2[C:13]3[CH2:21][CH2:20][CH2:19][CH2:18][C:14]=3[CH:15]=[CH:16][C:17]=2[N:8]([C:4]2[CH:3]=[C:2]([NH:1][S:34]([C:24]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:27]=[CH:26][CH:25]=3)(=[O:36])=[O:35])[CH:7]=[CH:6][CH:5]=2)[C:9]1=[O:23]

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 56640367HCID 56640367, compound

Product 1

HCID 86690027HCID 86690027, compoundYield 29%

Procedure

4-(3-Aminophenyl)-1,4,7,8,9,10-hexahydrobenzo[f]quinoxaline-2,3-dione (30 mg, 0.097 mmol) and 1-naphthalenesulfonyl chloride (33 mg, 0.146 mmol) were used in a process similar to Example 9 to give the titled compound (a white crystal, 14 mg, yield 29%).

Sources & evidence

ORD record
ord-100e487570f649818b3d64a1d37a66d2
Source dataset
uspto-grants-2014_03
Patent number
US08673915B2

Reaction notes

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