Hydrochloric Acid → 2-Chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A 500-mL round-bottom flask was charged with 2,6-dichloronicotinic acid (25.0 g, 130 mmol), NaOH solution (325 mL, 2N) and the solution was refluxed at 129° C. for 4 hours. The reaction mixture was cooled to room temperature and acidified with a 6N aq. HCl solution. The resulting precipitate was filtered and dried under reduced pressure yielding to the desired product (19.87 g, 88%).

Provenance & Evidence