Trifluoroacetic acid → (3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate

Participants

Reaction Steps

tert-Butyl 5-(2-trifluoromethylbenzoyl)-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-2-carboxylate (56.8 g) was stirred with 15 ml of 90 percent trifluoroacetic acid at RT for 3 h. The reaction mixture was concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 40.81 g (85%), M+H+: 283.14.

Provenance & Evidence