HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(((6-Chloropyridazin-3-yl)oxy)methyl)thiazole → {5-[6-(Thiazol-4-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(((6-Chloropyridazin-3-yl)oxy)methyl)thiazole | HCID 58075183 | — |
| Reactant | (3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate | HCID 86661599 | — |
| Product | {5-[6-(Thiazol-4-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone trifluoroacetate | HCID 86762299 | — |
Reaction Steps
(3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate (example 1b) (500 mg, 1.26 mmol) was reacted analogously to example 4b with 3-chloro-6-(thiazol-4-ylmethoxy)pyridazine (287.3 mg, 1.26 mmol). Yield: 36 mg (5%), M+H+: 474.26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673917B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-0d7ec2a37a734fa1a5c86e2e09daadbb |
| Source note | uspto-grants-2014_03 |