3,6-Dichloropyridazine → 3-Chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridazine

HRID 1186785Notes

Reaction equation

HRID 1186785 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[O:9]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[CH2:11][CH2:10]1>>[Cl:1][C:2]1[N:3]=[N:4][C:5]([O:16][CH2:15][CH:12]2[CH2:13][CH2:14][O:9][CH2:10][CH2:11]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 673313,6-DichloropyridazineHCID 2773573(Oxan-4-yl)methanol

Product 1

HCID 532566843-Chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridazine

Procedure

3,6-Dichloropyridazine (1.0 g, 6.712 mmol) was reacted analogously to example 4a with (tetrahydropyran-4-yl)methanol (779 mg, 6.712 mmol). Yield: 683 mg (45%), M+H+: 229.1.

Sources & evidence

ORD record
ord-d94b9a2a0cdd408eb03af4a420f10e0d
Source dataset
uspto-grants-2014_03
Patent number
US08673917B2

Reaction notes

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