HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 68058275, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reactant | 4-iodo-1-(2-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridine | HCID 66668476 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 68058275 | HCID 68058275 | — |
Reaction Steps
To a 48 mL pressure bottle containing Intermediate 76A (535 mg, 1.32 mmol) was added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (500 mg, 1.97 mmol), potassium acetate (520 mg, 5.30 mmol), and anhydrous DMSO (10 mL). The reaction mixture was flushed with argon, treated with PdCl2(dppf).CH2Cl2 (60 mg, 0.082 mmol), and heated to 105° C. for 1.25 h to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673922B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-2fe5135967934fb1b077a1bd24ef8b4b |
| Source note | uspto-grants-2014_03 |