1,4-Dioxane hydrochloride → (S)-2-(4-aminomethylbenzoylamino)-4-aminobutyric Acid

Participants

Reaction Steps

The compound obtained in Example 60-2 (49.7 mg) was dissolved in methanol (0.5 ml) and 4 mol/l hydrochloric acid/dioxane solution (0.5 ml) was added. The mixture was stirred for 1.5 hours at room temperature. After the reaction, the solvent was removed by distillation and the residue was dried using a vacuum pump to obtain the title compound (52.4 mg) as a white solid.

Provenance & Evidence