反应详情

A mixture of 5-bromo-4,7-dimethyl-2-benzofuran-1(3H)-one (0.7 g, 2.9 mmol), potassium vinyltrifluoroborate (0.544 g, 4 mmol) and Pd(dppf)2Cl2 (0.07 g) in 20 mL of EtOH and 20 mL of TEA was refluxed under N2 for 4 hours. The mixture was concentrated and the residue was purified by column chromatography to afford 4,7-Dimethyl-5-vinyl-2-benzofuran-1(3H)-one. 1H-NMR (400 MHz, CDCl3) δ ppm 7.30 (s, 1H), 6.85-6.92 (m, 1H), 5.70 (d, J=17.3 Hz, 1H), 5.40 (d, J=11.0 Hz, 1H), 5.18 (s, 2H), 2.64 (s, 3H), 2.24 (s, 3H).

1. temperaturewas refluxed under N2 for 4 hours
2. concentrationThe mixture was concentrated
3. customthe residue was purified by column chromatography