HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one → 5-Fluoro-4-(1-hydroxy-2-{4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)-2-(methyloxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one | HCID 59568671 | — |
| Reactant | 5-Fluoro-2-methoxy-4-oxiran-2-ylbenzonitrile | HCID 86647302 | — |
| Product | 5-Fluoro-4-(1-hydroxy-2-{4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)-2-(methyloxy)benzonitrile | HCID 49800468 | — |
Reaction Steps
5-fluoro-4-(1-hydroxy-2-{4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}ethyl)-2-(methyloxy)benzonitrile was prepared in a similar fashion to that described for the synthesis of EXAMPLE 12 starting from 5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one and 5-fluoro-2-(methyloxy)-4-oxiran-2-ylbenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673920B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-0fad906743ac435ebb3dd0cc49d29d9f |
| Source note | uspto-grants-2014_03 |