反应详情

To 2-methoxy-4-(1-oxopropan-2-yl)benzonitrile (0.020 g, 0.106 mmol) were added dichloromethane (15 mL) and 5-[1-hydroxy-2-(piperazin-1-yl)ethyl]-4-methyl-2-benzofuran-1(3H)-one hydrochloride [(0.037 g, 0.116 mmol), in dichloromethane (2 mL), and triethylamine (0.029 mL, 0.211 mmol)], and the mixture was stirred at room temperature for 0.5 h. Sodium triacetoxyborohydride (0.112 g, 0.529 mmol) was added, and the reaction mixture was stirred at room temperature for 24 h. The reaction was quenched with water (5 mL), and the organics were extracted with EtOAc (2×40 mL). The combined organic layers were washed with water (20 mL) and brine (20 mL) and dried (MgSO4). Filtration followed by concentration afforded an oily residue, which was purified via mass-directed reverse-phase HPLC followed by evaporation and drying of the pure fraction obtained which then converted to HCl salt by triturating in 1M HCl in diethyl ether (0.50 mL, 2 h). Evaporation and dried under vacuum provided 4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}-1-methylethyl)-2-(methyloxy)benzonitrile.

1. stirringthe reaction mixture was stirred at room temperature for 24 h
2. customThe reaction was quenched with water (5 mL)
3. extractionthe organics were extracted with EtOAc (2×40 mL)
4. washThe combined organic layers were washed with water (20 mL) and brine (20 mL)
5. dry with materialdried (MgSO4)
6. filtrationFiltration
7. concentrationfollowed by concentration
8. customafforded an oily residue, which
9. customwas purified via mass-directed reverse-phase HPLC
10. customfollowed by evaporation
11. customdrying of the pure fraction
12. customobtained which
13. customby triturating in 1M HCl in diethyl ether (0.50 mL, 2 h)
14. customEvaporation
15. customdried under vacuum