HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-4-(2-oxopropyl)benzonitrile → 4-(2-{4-[2-Hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}propyl)-2-(methyloxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-4-(2-oxopropyl)benzonitrile | HCID 66643865 | — |
| Reactant | 5-(1-hydroxy-2-piperazin-1-ylethyl)-4-methyl-3H-2-benzofuran-1-one;hydrochloride | HCID 66646501 | — |
| Product | 4-(2-{4-[2-Hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}propyl)-2-(methyloxy)benzonitrile | HCID 49801046 | — |
Reaction Steps
4-(2-{4-[2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl}propyl)-2-(methyloxy)benzonitrile was prepared in a similar fashion as described for the preparation of EXAMPLE 38 starting from 5-[1-hydroxy-2-(piperazin-1-yl)ethyl]-4-methyl-2-benzofuran-1(3H)-one hydrochloride and 2-methoxy-4-(2-oxopropyl)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673920B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-74af7045d66a4057b0cef363b511726a |
| Source note | uspto-grants-2014_03 |