Ethanol → HCID 49801329, compound

Participants

Reaction Steps

NaBH4 (308 mg, 8.15 mmol) was added to a 25 mL ethanol solution of 2,2′-piperazine-1,4-diylbis[1-(4-nitrophenyl)ethanone] (400 mg, 0.970 mmol) at 0° C. The reaction mixture was allowed to warm up to room temperature and stir overnight. The reaction mixture was poured into water and extracted twice with EtOAc. The combined organic layers were washed with brine twice, then dried over MgSO4, filtered, and evaporated to dryness. The residue was purified by preparative TLC using 5% methanol in DCM to yield 2,2′-piperazine-1,4-diylbis[1-(4-nitrophenyl)ethanol].

Provenance & Evidence