Formamide → HCID 178517953, compound

HRID 1187253Notes

Reaction equation

HRID 1187253 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4](O)=[O:5].O.[CH:13]([NH2:15])=O>>[Br:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:13][N:15]=[C:4]2[OH:5]

Participants

4

Reactant 3

HCID 713FormamideHCID 962WaterHCID 798582-Amino-5-bromobenzoic acid

Product 1

HCID 178517953HCID 178517953, compoundYield 95%

Conditions

Temperature
165 °C

Procedure

A suspension of 2-amino-5-bromobenzoic acid (5.4 g, 25 mmol) in formamide (40 ml) was heated at 165° C. for 6 hours. After cooling to room temperature, water (100 ml) was added to the reaction mixture. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a white solid (5.3 g, yield: 95%) which was characterized by its mass spectrum as follows: MS (m/z): 225 ([M+H]+, 100).

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. dry with materialdried over P2O5

Sources & evidence

ORD record
ord-5f567949ef4548f98b2cf7f001a04b16
Source dataset
uspto-grants-2014_03
Patent number
US08673929B2

Reaction notes

Loading…