4-Fluorophenylboronic acid → HCID 24962072, compound

HRID 1187264Notes

Reaction equation

HRID 1187264 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7](Br)[CH:8]=2)[N:3]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1.FC1C=CC(C2C=C3C(=CC=2)N=CN=C3O)=CC=1>>[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:22]3[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 59359765HCID 59359765, compoundHCID 178517960HCID 178517960, compound

Product 1

HCID 24962072HCID 24962072, compoundYield 97%

Procedure

This compound, prepared from 2-amino-6-bromo-4-(cyclopropylmethoxy)-quinazoline and 4-fluorophenylboronic acid in 97% yield, using the procedure described for the synthesis of 6-(4-fluorophenyl)-4-hydroxy-quinazoline, was characterized by its mass spectrum as follows: MS (m/z): 310 ([M+H]+, 100).

Sources & evidence

ORD record
ord-70d68f07884b4a66b327c5e393fc6f90
Source dataset
uspto-grants-2014_03
Patent number
US08673929B2

Reaction notes

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