4-Acetamidophenylboronic acid → HCID 24962439, compound

HRID 1187265Notes

Reaction equation

HRID 1187265 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](Br)[CH:8]=2)[N:3]=1.[C:17]([NH:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)(=[O:19])[CH3:18].FC1C=CC(C2C=C3C(=CC=2)N=CN=C3O)=CC=1>>[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:24]3[CH:25]=[CH:26][C:21]([NH:20][C:17](=[O:19])[CH3:18])=[CH:22][CH:23]=3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 27346574-Acetamidophenylboronic acidHCID 59359762HCID 59359762, compoundHCID 178517960HCID 178517960, compound

Product 1

HCID 24962439HCID 24962439, compoundYield 84%

Procedure

This compound, synthesized from 2-amino-6-bromo-4-isopropoxy-quinazoline and 4-acetamido-phenylboronic acid in 84% yield as a white solid using the procedure described for the synthesis of 6-(4-fluorophenyl)-4-hydroxy-quinazoline, was characterized by its mass spectrum as follows: MS (m/z): 298 ([M+H]+, 100).

Sources & evidence

ORD record
ord-f36824fd9dc648d2a28c3998249734ac
Source dataset
uspto-grants-2014_03
Patent number
US08673929B2

Reaction notes

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