4-Acetamidophenylboronic acid → HCID 24962799, compound

HRID 1187267Notes

Reaction equation

HRID 1187267 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](Br)[CH:8]=2)[N:3]=1.[C:19]([NH:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)(=[O:21])[CH3:20].FC1C=CC(C2C=C3C(=CC=2)N=CN=C3O)=CC=1>>[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:26]3[CH:27]=[CH:28][C:23]([NH:22][C:19](=[O:21])[CH3:20])=[CH:24][CH:25]=3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 3

HCID 27346574-Acetamidophenylboronic acidHCID 59359752HCID 59359752, compoundHCID 178517960HCID 178517960, compound

Product 1

HCID 24962799HCID 24962799, compoundYield 82%

Procedure

This compound, synthesized from 2-amino-6-bromo-4-(2,2,2-trifluoro-ethoxy)-quinazoline and 4-acetamido-phenylboronic acid in 82% yield using the procedure described for the synthesis of 6-(4-fluorophenyl)-4-hydroxy-quinazoline, was characterized by its mass spectrum as follows: MS (m/z): 377 ([M+H]+, 100)

Sources & evidence

ORD record
ord-0ebec615d80942d084e7f376be316752
Source dataset
uspto-grants-2014_03
Patent number
US08673929B2

Reaction notes

Loading…