Ethanol → HCID 24958428, compound

Participants

Reaction Steps

To absolute ethanol (10 ml) was added NaH (80 mg of a 60% dispersion in mineral oil, 2.0 mmol). The mixture was stirred at room temperature for 10 minutes. Then, 4-chloro-6-(4-fluorophenyl)-quinazoline (52 mg, 0.2 mmol) was added to this solution. The resulting mixture was stirred at room temperature for another 30 minutes. The solvents were evaporated in vacuo and the crude residue was purified by silica gel flash chromatography, the mobile phase being a mixture of ethanol and dichloromethane in a volume ratio of 1:100), yielding the title compound as a white solid (46 mg, yield: 88%) was characterized by its mass spectrum as follows: MS (m/z): 269 ([M+H]+, 100).

Provenance & Evidence