1,2-Dichloroethane → HCID 59359760, compound

Participants

Reaction Steps

To a solution of 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid (248.1 mg, 1 mmol), EDC (191.7 mg, 1 mmol) and HOBt (135.1 mg, 1 mmol) in DCM (3 mL), was added diisopropylethylamine (DIEA) (0.26 ml, 1.5 mmol). After stirring vigorously for 0.5 hours, 2-pyrrolidin-1-yl-ethylamine (0.15 ml, 1.2 mmol) was added. The mixture was stirred overnight, diluted with EtOAc (20 ml) and washed twice with brine. The organic layer was dried with sodium sulfate and concentrated to provide the crude product (230 mg, 66.8% yield), which used without further purification.

Provenance & Evidence