4-(Methylcarbamoyl)benzeneboronic acid → HCID 68604098, compound

HRID 1187275Notes

Reaction equation

HRID 1187275 reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]3[CH:19]=[CH:18]S[CH:16]=3)[CH:13]=2)[N:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2].BrC1[CH:22]=[C:23]2C(=CC=1)N=[CH:26][N:25]=[C:24]2[O:31]C(C)C.CNC(C1C=CC(B(O)O)=CC=1)=O>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]3[CH:19]=[CH:18][C:23]([C:24]([NH:25][CH3:26])=[O:31])=[CH:22][CH:16]=3)[CH:13]=2)[N:8]=[CH:7][N:6]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 27735264-(Methylcarbamoyl)benzeneboronic acidHCID 59359757HCID 59359757, compoundHCID 59359758HCID 59359758, compound

Product 1

HCID 68604098HCID 68604098, compound

Procedure

The title compound was prepared in an analogous method to 4-isopropoxy-6-thiophene-3-yl-quinazoline, starting with 6-Bromo-4-isopropoxy-quinazoline and using 4-(N-methylaminocarbonyl)phenyl boronic acid. The product was characterized by its mass spectrum MS and HPLC retention time: MS (m/z) 321.03 [M+H]+; HPLC Rt=1.66 minutes (Method A).

Sources & evidence

ORD record
ord-1b57fee12f3c425e9f1f456ffe2f9b4b
Source dataset
uspto-grants-2014_03
Patent number
US08673929B2

Reaction notes

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