Benzyl (2,4-difluoro-3-formylphenyl)carbamate → HCID 178507660, compound

HRID 1187290Notes

Reaction equation

HRID 1187290 reaction equation
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[C:4]([OH:10])=[N:3][CH:2]=1.C(OC(=O)[NH:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[C:23]([CH:28]=[O:29])[C:22]=1[F:30])C1C=CC=CC=1>>[NH2:20][C:21]1[C:22]([F:30])=[C:23]([C:28]([C:9]2[C:5]3[C:4]([OH:10])=[N:3][CH:2]=[N:1][C:6]=3[NH:7][CH:8]=2)=[O:29])[C:24]([F:27])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 58086235Benzyl (2,4-difluoro-3-formylphenyl)carbamateHCID 178518057HCID 178518057, compound

Product 1

HCID 178507660HCID 178507660, compound

Procedure

(3-Amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone 39 is synthesized in two steps from 7H-pyrrolo[2,3-d]pyrimidin-4-ol 37 and (2,4-difluoro-3-formyl-phenyl)-carbamic acid benzyl ester 33 as shown in Scheme 1g.

Sources & evidence

ORD record
ord-b2f56407167f49bb809b94a24d5156e0
Source dataset
uspto-grants-2014_03
Patent number
US08673928B2

Reaction notes

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