反应详情

To N,N-diisopropylamine (4.50 mL, 32.1 mmol) in 130 mL of tetrahydrofuran, n-butyllithium (12.8 mL, 2.50 M in hexane, 32.1 mmol) is added at −78° C. under nitrogen. After 15 minutes, N-(2,4-difluoro-phenyl)-4-ethyl-benzenesulfonamide (60, 4.344 g, 14.61 mmol) in 20 mL of tetrahydrofuran is added at −78° C. under nitrogen. After 30 minutes, N,N-dimethylformamide (2.83 mL, 36.5 mmol) is added and the reaction continued at −78° C. under nitrogen for 1 hour, then warmed to room temperature over 60 minutes. The reaction is quenched with 6 mL of 6 N aqueous hydrochloric acid. The aqueous layer is extracted with ethyl acetate. The organic layers are combined and washed with brine, dried over magnesium sulfate, filtered and the filtrate concentrated under vacuum. The resulting material is purified by silica gel column chromatography eluting with a gradient of 5-35% ethyl acetate in hexane. Appropriate fractions are combined and concentrated under vacuum to provide the desired compound (61, 2.634 g). MS (ESI) [M−H+]−=324.2.

1. waitAfter 30 minutes
2. waitthe reaction continued at −78° C. under nitrogen for 1 hour
3. customThe reaction is quenched with 6 mL of 6 N aqueous hydrochloric acid
4. extractionThe aqueous layer is extracted with ethyl acetate
5. washwashed with brine
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. concentrationthe filtrate concentrated under vacuum
9. customThe resulting material is purified by silica gel column chromatography
10. washeluting with a gradient of 5-35% ethyl acetate in hexane
11. concentrationconcentrated under vacuum