4-Ethylbenzene-1-sulfonyl chloride → HCID 53238437, compound

HRID 1187305Notes

Reaction equation

HRID 1187305 reaction equation
[NH2:1][C:2]1[C:3]([F:22])=[C:4]([C:9]([C:11]2[C:19]3[C:18]([O:20][CH3:21])=[N:17][CH:16]=[N:15][C:14]=3[NH:13][CH:12]=2)=[O:10])[C:5]([F:8])=[CH:6][CH:7]=1.[CH2:23]([C:25]1[CH:30]=[CH:29][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:27][CH:26]=1)[CH3:24]>>[F:22][C:3]1[C:4]([C:9]([C:11]2[C:19]3[C:18]([O:20][CH3:21])=[N:17][CH:16]=[N:15][C:14]=3[NH:13][CH:12]=2)=[O:10])=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:31]([C:28]1[CH:29]=[CH:30][C:25]([CH2:23][CH3:24])=[CH:26][CH:27]=1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 5709594-Ethylbenzene-1-sulfonyl chlorideHCID 57963243HCID 57963243, compound

Product 1

HCID 53238437HCID 53238437, compound

Procedure

N-[2,4-Difluoro-3-(4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-ethyl-benzenesulfonamide P-1008 is prepared in one step from (3-amino-2,6-difluoro-phenyl)-(4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone 36 and 4-ethyl-benzenesulfonyl chloride 59 as shown in Scheme 4.

Sources & evidence

ORD record
ord-b9a4ef81b5a8470db0858c28600d4959
Source dataset
uspto-grants-2014_03
Patent number
US08673928B2

Reaction notes

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