(S)-methyl 2-(piperidin-3-yl)acetate hydrochloride → (R)-2-(1-(5-(Cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-methyl 2-(piperidin-3-yl)acetate hydrochloride	HCID 45073966	—
Reactant	6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide	HCID 59830657	—
Product	(R)-2-(1-(5-(Cyclohexylcarbamoyl)-3-fluoro-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid	HCID 59830628	—

Reaction Steps

Prepared in a similar manner to that described above from 6-chloro-N-cyclohexyl-5-fluoro-2-(propylthio)nicotinamide using (S)-methyl 2-(piperidin-3-yl)acetate hydrochloride followed by an ester hydrolysis as described above to give the desired compound (190 mg) as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673938B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-b9d515ebd1864db7ace8bcdf782207af
Source note	uspto-grants-2014_03