Acetone → HCID 58835285, compound

Participants

Reaction Steps

Acetone (1 mL) was added to a suspension of 1-[3-(aminooxy)propyl]-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine (0.237 g, 0.92 mmol) in methanol (6 mL) at room temperature. The mixture was stirred and eventually a solution formed. After 6 hours, the volatiles were removed and the crude product was purified by chromatography on a HORIZON HPFC system (silica gel, gradient elution with 0-25% CMA in chloroform) to give a white powder that was crystallized from acetonitrile to yield 0.110 g of acetone O-[3-(4-amino-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)propyl]oxime as white needles, mp 120-121° C.

Provenance & Evidence