Acetic Anhydride → HCID 69184344, compound

Participants

Reaction Steps

A mixture of 2-{2-[(3-nitroquinolin4-yl)ammo]ethoxy}ethanol (55.5 g, 0.2 mol), acetic anhydride (37.6 mL, 0.4 mol), and pyridine (250 mL) was heated at reflux for 30 minutes. The solution was allowed to cool to ambient temperature and was concentrated under reduced pressure to remove about 50-75% of the pyridine. The residual solution was poured into water to precipitate the product as an oil which solidified upon stirring. The solid was isolated by filtration, washed with water, and dried. The crude product was recrystallized from 2-propanol (200 mL) to provide 55.6 g of 2-{2-[(3-nitroquinolin-4-yl)amino]ethoxy}ethyl acetate as a bright yellow solid.

Provenance & Evidence