HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)pyridine → (S)-4-Chloro-N-[1-(4-fluorophenyl)ethyl]-6-(pyridin-2-yl)pyrimidine-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)pyridine | HCID 607784 | — |
| Reactant | (S)-4,6-Dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidin-2-amine | HCID 86659372 | — |
| Catalyst | Copper oxide | HCID 14829 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | (S)-4-Chloro-N-[1-(4-fluorophenyl)ethyl]-6-(pyridin-2-yl)pyrimidine-2-amine | HCID 86659382 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
200 mg of (S)-4,6-dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidine-2-amine (Reference Example 1), 0.22 ml 2-(tributylstannyl)pyridine, 55 mg of copper oxide and 81 mg of tetrakis(triphenylphosphine)palladium were added in turn to degassed toluene, and the mixture was stirred at 110° C. for 4 hours under argon atmosphere. The reaction solution was purified by silica gel column chromatography to obtain 63 mg of the objective compound as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673891B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-02ee174af3af4956acf388ed8d2b964b |
| Source note | uspto-grants-2014_03 |