참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-(Hydroxymethyl)-4-piperidinol hydrochloride | HCID 22744472 | — |
| 반응물 | (S)-4,6-Dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidin-2-amine | HCID 86659372 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 86659399 | HCID 86659399 | 97.2% |
반응 단계
150 mg of (S)-4,6-dichloro-N-[1-(4-fluorophenyl)ethyl]pyrimidine-2-amine and 97 mg of 4-(hydroxymethyl)piperidin-4-ol hydrochloride were dissolved in 3 ml of 2-ethoxyethanol, and 274 μl of N,N-diisopropylethylamine was added thereto, and the mixture was stirred at 135° C. for 20 hours. The reaction solution was air-cooled to room temperature, and then diluted with ethyl acetate. The solution was washed in turn with water and brine and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 194 mg of the objective compound as brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08673891B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_03 |
|---|
| ORD ID | ord-4dc904e3b3394660b648d25f4ef9e49f |
|---|
| 출처 메모 | uspto-grants-2014_03 |
|---|
