HCID 67156334, compound → HCID 67151537, compound

Participants

Reaction Steps

To a solution of [(E)-(S)-3-(4-bromo-phenyl)-1-hydroxymethyl-allyl]-carbamic acid tert-butyl ester (14.7 g) in methanol (150 ml) was added 10% Pt/C (1.68 g) and the resulting mixture was stirred under a H2 balloon at room temperature for 3 hours (whereby the reaction progress was checked continuously by 1H NMR). The reaction mixture was filtered through celite and the filtrate was concentrated in vacuo to afford [(S)-3-(4-bromo-phenyl)-1-hydroxymethyl-propyl]-carbamic acid tert-butyl ester as a yellow solid (11.5 g, 78%). MS (ISP): 346.0 ([{81Br}M+H]+), 344.0 ([{79Br}M+H]+), 289.9 ([{81Br}M+H—C4H8]+), 288.0 ([{79Br}M+H—C4H8]+), 246.1 ([{81Br}M+H—C4H8—CO2]+), 244.1 ([{79Br}M+H—C4H8—CO2]+).

Provenance & Evidence