4-hydroxymethyl-5-methyl-1H-imidazole → HCID 68822530, compound

HRID 1188011Notes

Reaction equation

HRID 1188011 reaction equation
[OH:1][CH2:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1C.COC(=O)C1C=CC(CBr)=CC=1.[CH2:21]([O:23][C:24]([C:26]1[O:27][C:28]([CH2:31]Cl)=[CH:29][CH:30]=1)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24]([C:26]1[O:27][C:28]([CH2:31][N:4]2[C:3]([CH2:2][OH:1])=[CH:7][N:6]=[CH:5]2)=[CH:29][CH:30]=1)=[O:25])[CH3:22]

Participants

4

Reactant 3

HCID 1224334-hydroxymethyl-5-methyl-1H-imidazoleHCID 256687Methyl 4-(bromomethyl)benzoateHCID 263166Ethyl 5-(chloromethyl)-2-furancarboxylate

Product 1

HCID 68822530HCID 68822530, compound

Procedure

The following compounds were obtained using the same procedure as in Example A1 but replacing 4-hydroxymethylimidazole hydrochloride with 4-hydroxymethyl-5-methylimidazole and 4-bromomethylbenzoic acid methyl ester by 5-chloromethylfuran-2-carboxylic acid ethyl ester.

Workup

  1. customThe following compounds were obtained

Sources & evidence

ORD record
ord-bfee7345f0a54e8487968f041d0959a8
Source dataset
uspto-grants-2014_03
Patent number
US08673955B2

Reaction notes

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