反应详情

温度

80 °C

4-Acetamido-3-nitrobenzaldehyde (2.08 g, 10 mmol) was dissolved in methanol (200 mL). The solution was added with aqueous 2 N HCl (50 mL), and refluxed by heating at 80° C. for 8 hours under an argon flow. The reaction mixture was concentrated under reduced pressure to remove the methanol, and the residue was made basic with aqueous 2 N NaOH, and extracted 5 times with dichloromethane. The organic phases were combined, dried over anhydrous Na2SO4, and concentrated under reduced pressure to obtain the target compound as yellow solid (1.62 g, yield: 98%).

1. temperaturerefluxed
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customto remove the methanol
4. extractionextracted 5 times with dichloromethane
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated under reduced pressure