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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188032Generated: October 26, 2026

1-Chloropinacolone → 4-(4-tert-butylthiazol-2-ylamino)-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

https://huagongshe.com/reaction/1188032

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-ChloropinacoloneHCID 83572—
ReactantN,N-dicyclopropyl-6-ethyl-1-methyl-4-thioureido-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamideHCID 58180527—
Product4-(4-tert-butylthiazol-2-ylamino)-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamideHCID 58180501—

Reaction Steps

Prepared from N,N-dicyclopropyl-6-ethyl-1-methyl-4-thioureido-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (example 2B) and 1-chloro-3,3-dimethylbutan-2-one using the same procedure as reported for 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673933B2
Source datasetuspto-grants-2014_03
ORD IDord-477d0c0fb4e747cfb40eef597ffdcb36
Source noteuspto-grants-2014_03